2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Adrenergic Receptor

Adrenergic Receptor

Beta Receptor

Adrenergic Receptor

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Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

Adrenergic Receptor Isoform Specific Products:

Adrenergic Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0431AR
    Phenoxybenzamine hydrochloride (Standard)
    		Antagonist
    Phenoxybenzamine (hydrochloride) (Standard) is the analytical standard of Phenoxybenzamine (hydrochloride). This product is intended for research and analytical applications. Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine hydrochloride also shows antitumor activity.
    Phenoxybenzamine hydrochloride (Standard)
  • HY-131104S
    Brombuterol-d9
    		Agonist 99.0%
    Brombuterol-d9 is a deuterium labeled Brombuterol. Brombuterol is a β-adrenergic receptor agonist.
    Brombuterol-d<sub>9</sub>
  • HY-B0804S
    Nadolol-d9
    		Antagonist
    Nadolol-d9 is the deuterium labeled Nadolol. Nadolol is a non-selective and orally active β-adrenergic receptors blocker.
    Nadolol-d<sub>9</sub>
  • HY-134577
    Clorprenaline
    		Agonist 99.33%
    Clorprenaline is a potent agonist of β2-adrenergic. Clorprenaline promotes animal muscular mass growth and decreases fat accumulation. Clorprenaline is a potential new lean meat-boosting feed additive.
    Clorprenaline
  • HY-17034AR
    Dexmedetomidine hydrochloride (Standard)
    		Agonist
    Dexmedetomidine (hydrochloride) (Standard) is the analytical standard of Dexmedetomidine (hydrochloride). This product is intended for research and analytical applications. Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects.
    Dexmedetomidine hydrochloride (Standard)
  • HY-B0437AS
    Sotalol-d6 hydrochloride
    		Antagonist 98.01%
    Sotalol-d6 (hydrochloride) is a deuterium labeled Sotalol hydrochloride. Sotalol hydrochloride is an orally active, non-selective competitive β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels.
    Sotalol-d<sub>6</sub> hydrochloride
  • HY-101338
    RS-79948-197
    		Antagonist
    RS-79948-197 is a non-imidazoline α2-adrenoceptor antagonist. RS-79948-197 shows Kd values of 0.42 nM, 0.18 nM, 0.19 nM, 0.60 nM, 0.46 nM, and 0.77 nM for rat α2A, rat α2B, rat α2C, human α2A, human α2B, and human α2C, respectively.
    RS-79948-197
  • HY-P3557A
    Mibenratide TFA
    		Antagonist
    Mibenratide TFA, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide TFA can be used for heart failure research.
    Mibenratide TFA
  • HY-U00123A
    Guanoxabenz hydrochloride
    		Agonist 99.72%
    Guanoxabenz (Hydroxyguanabenz) hydrochloride is an α2 adrenergic receptor agonist, with a Ki of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor.
    Guanoxabenz hydrochloride
  • HY-16056
    Arbutamine
    		Agonist ≥98.0%
    Arbutamine is a short-acting, potent and nonselective β-adrenoceptor agonist. Arbutamine stimulates cardiac β1-, tracheal β2-, and adiopocyte β3- adrenergic receptors. Arbutamine provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine can be used for cardiac stress agent .
    Arbutamine
  • HY-12749AS
    Midodrine-d6 hydrochloride
    		99.44%
    Midodrine-d6 (hydrochloride) is a selective and orally active adrenergic α1-receptor agonist. Midodrine-d6 (hydrochloride) can strengthen vascular contraction. Midodrine-d6 (hydrochloride) can be used for the researches of cardiovascular disease, such as orthostatic hypotension.
    Midodrine-d<sub>6</sub> hydrochloride
  • HY-107326
    Bunazosin
    		Antagonist 98.52%
    Bunazosin is a potent and selective α1-adrenoceptor antagonist. Bunazosin can be used for antihypertensive and ocular hypotensive research.
    Bunazosin
  • HY-N0378S2
    D-Mannitol-13C6
    		Activator 98.0%
    D-Mannitol-13C6 is the 13C labeled D-Mannitol (HY-N0378). D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed.
    D-Mannitol-<sup>13</sup>C<sub>6</sub>
  • HY-100850
    Piperoxan hydrochloride
    		Antagonist 99.66%
    Piperoxan (Benodaine) hydrochloride is an α2 adrenoceptor antagonist. Piperoxan hydrochloride is the first-generation antihistamine.
    Piperoxan hydrochloride
  • HY-N0378S1
    D-Mannitol-13C
    		Activator 99.0%
    D-Mannitol-13C is the 13C labeled D-Mannitol (HY-N0378). D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed.
    D-Mannitol-<sup>13</sup>C
  • HY-100634
    4-Hydroxypropranolol hydrochloride
    		Antagonist
    4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol. 4-Hydroxypropranolol hydrochlorid is of comparable potency to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties.
    4-Hydroxypropranolol hydrochloride
  • HY-148529
    Midaglizole
    		Antagonist 98.28%
    Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo.
    Midaglizole
  • HY-B0528AS
    Octopamine-d4 hydrochloride
    		Agonist 98.28%
    Octopamine-d4 (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure.
    Octopamine-d<sub>4</sub> hydrochloride
  • HY-106769
    Fluparoxan
    		Antagonist 99.66%
    Fluparoxan is an orally active, selective and competitive alpha 2-adrenoceptor antagonist. Fluparoxan is an anti-depressant agent.
    Fluparoxan
  • HY-103212A
    Azepexole hydrochloride
    		Agonist
    Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist for α 2-adrenoceptor, with pKi of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions with IC50 of 78.72 nM. Azepexole hydrochloride exhibits antitussive and analgesic efficacy.
    Azepexole hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
Adrenergic Receptor Isoform Comparison

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